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Selleck Chemical LLC NE 52-QQ57
SDP

Catalog No. 5000002853
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NE 52-QQ57 is a selective and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0 07 M NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26 8 nM in HEK293 cells The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules including tumor necrosis factor- (TNF- ) interleukin (IL)-1 IL-6 inducible nitric oxide synthase (iNOS) nitric oxide (NO) cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2)

Catalog No. 50-000-02853 Supplier Selleck Chemical LLC Supplier No. S68505MG
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NE 52-QQ57 is a selective and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0 07 M NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26 8 nM in HEK293 cells The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules including tumor necrosis factor- (TNF- ) interleukin (IL)-1 IL-6 inducible nitric oxide synthase (iNOS) nitric oxide (NO) cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2)

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