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Genscript Corporation Nectin-2/CD112 Fc Chimera Hum
Supplier: Genscript Corporation Z0345650
Nectin-2 also known as CD112 (Cluster of Differentiation 226) and PVRL2 (Poliovirus receptor-related 2) is a human plasma membrane glycoprotein This protein is a modulator of T-cell signaling and can be either a costimulator of T-cell function or a coinhibitor depending on the receptor it binds to Upon binding to CD226 it stimulates T-cell proliferation and cytokine production including that of IL-2 IL-5 IL-10 IL-13 and IFN It can also inhibit T-cell proliferation upon interaction with PVRIG Nectin-2 also acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1 herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)
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