Medchemexpress LLC Nelfinavir Mesylate (AG 1343 Mesylate) | 159989-65-8 | C33H49N3O7S2 | 50 MG

Supplier:  Medchemexpress LLC HY15287A50MG

Nelfinavir Mesylate is a potent, orally bioavailable inhibitor of HIV-1 protease (Ki=2 nM) used in the treatment of HIV infection. It also acts as a broad-spectrum anticancer agent.

• Potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection.
• Functions as a broad-spectrum anticancer agent.
• Inhibits the proliferation of multiple myeloma cells in a dose-dependent manner (IC50 of 1-5 μM).
• Impairs 26S chymotrypsin-like proteasome activity.
• Triggers apoptosis in myeloma cell lines and fresh plasma cells.
• Decreases the phosphorylation of AKT, STAT-3, and ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system.
• Also identified as a SARS-CoV 3CLpro inhibitor with an IC50 of 35.93 μM.

Catalog No. 50-003-73590