Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Neomycin sulfate(Synonyms: Neomycin sulphate, Fradiomycin sulfate, Neomycin trisulfate salt hydrate, Neosulf), 10g, CAS: 1405-10-3.
Supplier: Apexbio Technology LLC B179510000
Neomycin sulfate (CAS 1405-10-3) is an aminoglycoside antibiotic that interacts with nucleic acid structures and ion channels influencing several biological processes It inhibits hammerhead ribozyme cleavage reactions by preferentially stabilizing the ribozyme-substrate ground-state complex thereby impeding catalytic turnover In HIV-1 research neomycin disrupts the interaction between Tat protein and the viral RNA TAR element via an allosteric noncompetitive mechanism Additionally neomycin binds specifically to DNA triplex structures particularly stabilizing TAT triplets It also demonstrates voltage- and concentration-dependent blockage of ryanodine receptor channels mainly from the luminal side These properties make neomycin sulfate valuable for mechanistic studies involving RNA/DNA structure interactions and channel functions
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?