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Apexbio Technology LLC Nepafenac 78281-72-8 25mg
Supplier: Apexbio Technology LLC A289025
Nepafenac (CAS 78281-72-8) is a small-molecule inhibitor targeting cyclooxygenase enzymes COX-1 and COX-2 It is designed to inhibit these enzymes thereby reducing prostaglandin E2 (PGE2) biosynthesis and modulating ocular inflammatory pathways Nepafenac exerts its biological activity primarily through COX-1 and COX-2 inhibition In cell-based studies nepafenac demonstrates inhibitory activity with IC50 values of approximately 250 nM for COX-1 and 150 nM for COX-2 In LPS-induced inflammation models topical application reduces retinal PGE2 concentrations Additionally it has been studied as an inhibitor of cellular proliferation in human uveal melanoma cell lines (SP6 5 92 1 OCM-1 MKT-BR UW-1) Based on these pharmacological properties nepafenac holds research potential in ophthalmologic studies involving inflammatory pathways and ocular malignancies
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