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Apexbio Technology LLC Nepicastat (SYN-117) HCl 170151-24-3 50mg
Supplier: Apexbio Technology LLC A433250
Nepicastat (SYN-117) HCl is a potent and selective inhibitor targeting dopamine -hydroxylase (DBH) an enzyme responsible for converting dopamine to norepinephrine in catecholamine biosynthesis pathways By inhibiting DBH activity Nepicastat decreases norepinephrine synthesis and concurrently elevates dopamine levels Preclinical studies conducted in animal models such as spontaneously hypertensive rats and canine models demonstrate a dose-dependent reduction of norepinephrine levels accompanied by elevation of dopamine concentration across central nervous system and cardiac tissues Nepicastat serves as a valuable research tool in investigating catecholamine homeostasis cardiovascular function sympathetic regulation and dopamine-mediated neurotransmission
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