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AdipoGen Neratinib
SDP

Supplier:  AdipoGen CDXN0326M100

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Chemical. CAS 698387-09-6. Formula C30H29ClN6O3. MW 557. Neratinib is a cell-permable, irreversible, selective inhibitor of the HER2 kinase IC50=59nM and EGFR IC50=92nM by preventing phosphorylation of these proteins by their respective kinases. It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib. Neratinib displays activity against a variety of cancer cell lines, including A431, 3T3, and MDA-MB-435. Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.

Catalog No. 50-256-0366


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