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Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 100 MG
Supplier: Medchemexpress LLC HY32721B100MG
Neratinib maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. It is for research use only.
- Orally available
- Irreversible inhibitor
- Highly selective HER2 and EGFR inhibitor
- Inhibits proliferation of cell lines with high HER-2 levels
- Less active in cell lines expressing neither HER-2 nor EGFR
- Arrests BT474 cell cycle at G1-S phase
- Inhibits MAPK and Akt phosphorylation
- Down-regulates cyclin D1 levels
- Induces p27
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