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Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 25 MG
Supplier: Medchemexpress LLC 25MGHY32721B
Neratinib maleate is an orally available, irreversible, and highly selective inhibitor of HER2 and EGFR, intended for research use only. It inhibits the proliferation of cell lines expressing high levels of HER-2 and demonstrates anticancer activities in vivo by reducing tumor growth in a dose-dependent manner in various xenografts.
- Orally available, irreversible, highly selective HER2 and EGFR inhibitor.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase.
- Inhibits MAPK and Akt phosphorylation.
- Down-regulates cyclin D1 levels and induces p27.
- Shows anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
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