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Medchemexpress LLC Neratinib (maleate) | 915942-22-2 | 99.7% | 673.11 | 5 MG
Supplier: Medchemexpress LLC HY32721B5MG
Neratinib maleate is an orally available, irreversible, and highly selective inhibitor of HER2 and EGFR. It effectively inhibits the proliferation of cell lines expressing high levels of HER-2 and shows anticancer activities in tumor xenograft models. This compound induces G1-S phase arrest and leads to inhibition of MAPK and Akt phosphorylation.
- Orally available
- Irreversible, highly selective HER2 and EGFR inhibitor
- Inhibits proliferation of HER-2 expressing cell lines
- Induces G1-S phase arrest
- Inhibits MAPK and Akt phosphorylation
- Shows anticancer activity in tumor xenograft models
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