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Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY32721B50MG

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Neratinib maleate (HKI-272 maleate) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor. It is intended for research use only.

  • Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM, respectively.
  • Demonstrates antiproliferative effects in cell lines with high HER-2 levels.
  • Arrests cell cycle at G1-S phase in BT474 cells.
  • Inhibits MAPK and Akt phosphorylation, and induces p27.
  • Exhibits anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
  • Reduces tumor growth in xenograft models.

Catalog No. 50-004-01585


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