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Medchemexpress LLC Nesuparib | 2055357-64-5 | 99.5% | C23H24N6O | 100 MG
Supplier: Medchemexpress LLC HY145584100MG
Nesuparib is an orally active inhibitor for PARP 1/2 and Tankyrase 1/2, inhibiting tankyrases 1, tankyrases 2, and PARP 1. It demonstrates antitumor activity and is used in research for advanced solid tumors. This compound inhibits tankyrases, stabilizes AXIN protein, and impacts its downstream signaling pathways (WNT/β-catenin and Hippo signaling pathway), leading to an antitumor effect.
- Inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1, and 2 nM
- Exhibits antitumor activity against Olaparib-resistant breast and ovary cancer
- Stabilizes AXIN protein and impacts WNT/β-catenin and Hippo signaling pathways
- Used in research for advanced solid tumors
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