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Medchemexpress LLC Nesuparib | 2055357-64-5 | 99.5% | C23H24N6O | 50 MG
SDP

Catalog No. 5000355294
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Nesuparib (JPI-547) is an orally active inhibitor for PARP 1/2 and Tankyrase 1/2. It inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1, and 2 nM, respectively. It demonstrates antitumor activity and is used in research of advanced solid tumors.

  • Orally active inhibitor for PARP 1/2 and Tankyrase 1/2
  • Inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1, and 2 nM
  • Demonstrates antitumor activity
  • Used in research of advanced solid tumors
  • Inhibits tankyrases, stabilizes AXIN protein, and impacts WNT/β-catenin and Hippo signaling pathways, leading to an antitumor effect
  • Shows promising antitumor activity against olaparib-resistant breast and ovary cancer in mouse xenograft models

Catalog No. 50-003-55294 Supplier Medchemexpress LLC Supplier No. HY14558450MG
May include imposed supplier surcharges.
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Nesuparib (JPI-547) is an orally active inhibitor for PARP 1/2 and Tankyrase 1/2. It inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1, and 2 nM, respectively. It demonstrates antitumor activity and is used in research of advanced solid tumors.

  • Orally active inhibitor for PARP 1/2 and Tankyrase 1/2
  • Inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1, and 2 nM
  • Demonstrates antitumor activity
  • Used in research of advanced solid tumors
  • Inhibits tankyrases, stabilizes AXIN protein, and impacts WNT/β-catenin and Hippo signaling pathways, leading to an antitumor effect
  • Shows promising antitumor activity against olaparib-resistant breast and ovary cancer in mouse xenograft models

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