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Medchemexpress LLC Netropsin dihydrochloride | 18133-22-7 | 1 MG

Supplier: Medchemexpress LLC HYN6800A1MG
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic. It inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. It also possesses antibacterial and antiviral activity.
- Potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner.
- Improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter.
- Radioprotective ability against radiation-induced damage in solutions of DNA due to high binding affinity and structural stabilization.
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