Cayman Chemical NG 25hydrochlorIde hydrate 1mg

Supplier:  Cayman Chemical 275791 MG

An inhibitor of MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively); also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively); prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells at 100 nM; inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively, in Gen2.2 cells; decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells; reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer

Catalog No. 50-294-0640