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Medchemexpress LLC NG-497 | 2598242-66-9 | 99.07% | 315.36 | 1 ML
Supplier: Medchemexpress LLC HY14875610MM/1ML
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. It has potential value for tumor research. NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases, and abolishes human adipocytes in a dose-dependent and reversible manner lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.
- Selective human ATGL inhibitor
- Targets enzymatically active patatin-like domain
- Potential for tumor research
- Selectively inactivates human and nonhuman primate ATGL
- Abolishes human adipocytes in a dose-dependent and reversible manner lipolysis
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