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Medchemexpress LLC NH-3 | 447415-26-1 | 99.4% | C28H27NO6 | 100 MG
Supplier: Medchemexpress LLC HY141513100MG
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. It is derived from the selective thyromimetic GC-1 and inhibits the binding of thyroid hormones to their receptor and also inhibits cofactor recruitment. NH-3 also functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Orally active, reversible thyroid hormone receptor antagonist
- Inhibits thyroid hormone binding to its receptor and cofactor recruitment
- Functions as a click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition
- Modestly decreases heart rate in vivo
- Inhibits tachycardic and TSH suppressant effects in vivo
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