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Medchemexpress LLC NH-3 | 447415-26-1 | 99.4% | C28H27NO6 | 50 MG
Supplier: Medchemexpress LLC HY14151350MG
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. It is a derivative of the selective thyromimetic GC-1 and works by inhibiting the binding of thyroid hormones to their receptor, thereby inhibiting cofactor recruitment. Additionally, NH-3 is a click chemistry reagent containing an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups.
- Orally active, reversible thyroid hormone receptor antagonist
- IC50 of 55 nM (THR)
- Inhibits binding of thyroid hormones to their receptor
- Click chemistry reagent with alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition
- Modestly decreases heart rate in vivo
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