Medchemexpress LLC NI-57 | 1883548-89-7 | 99.4% | 383.42 | 50 MG

Supplier:  Medchemexpress LLC HY1953750MG

NI-57 is a chemical probe and an inhibitor of the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins. It exhibits IC50s of 3.1, 46, and 140 nM for BRPF1, BRPF2 (BRD1), and BRPF3, respectively. It is intended for research use only and not for sale to patients.

• Inhibits BRPF family proteins with varying IC50s (3.1 nM for BRPF1, 46 nM for BRPF2 (BRD1), and 140 nM for BRPF3).
• Binds to the BRD of BRPF1 with a Kd of 31 ± 2 nM, BRD1 with a Kd of 110 ± 13 nM, and BRPF3 with a Kd of 410 ± 47 nM.
• Shows less activity on BRD9 (IC50, 520 nM) and BRD4 (BD1) (IC50, 3700 nM), and TRIM24 (IC50, 1600 nM).
• Inhibits BRPF BRDs in the nucleus.
• Reduces CCL-22 gene expression by 27.7 ± 9.4% at 10 μM.
• Has favorable oral bioavailability in mice.

Catalog No. 50-004-03291