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Cayman Chemical NIcergolIn 100mg

Supplier: Cayman Chemical 31573100 MG
An α1-AR antagonist; binds to α1-ARs in rat brain membranes (Ki = 12.5 nM); inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively); inhibits cirazoline-induced pressor responses in rats at 0.5 UG/kg per minute, i.v.; improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg; increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
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