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Medchemexpress LLC Nicorandil | 65141-46-0 | 98.2% | 5 G
Supplier: Medchemexpress LLC HYB03415G
Nicorandil is a potent potassium channel activator that targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). It is a nicotinamide ester with vasodilatory and cardioprotective effects, and it has potential uses for angina and ischemic heart diseases. This process results in relaxation of smooth muscle and coronary vasodilation.
- Potent potassium channel activator
- Targets vascular nucleoside diphosphate-dependent K+ channels
- Targets cardiac ATP-sensitive K+ channels (KATP)
- Displays vasodilatory and cardioprotective effects
- Potential use for angina and ischemic heart diseases
- Activates ATP-sensitive K+ channels composed of Kir6.2 and SUR2A or 2B
- Stimulates guanylate cyclase to increase cyclic GMP (cGMP) formation
- Appears as a white to off-white solid
- Has a melting point of 92°C
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