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Apexbio Technology LLC Nicotinamide(Synonyms: Nicotinic acid amide, Vitamin B3 amide, Niacinamide, Pyridine-3-carboxamide, 3-Pyridinecarboxamide), 1g, CAS: 98-92-0.
Supplier: Apexbio Technology LLC N16511000
Nicotinamide (CAS 98-92-0) is a small-molecule inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) an enzyme critical in DNA repair pathways Under pathological conditions such as ischemia or trauma PARP-1 hyperactivation depletes cellular NAD triggering neuronal cell death In vitro studies indicate that transporter-mediated uptake of nicotinamide confers protection against PARP-1-induced astrocyte injury In vivo studies in diabetic rat models demonstrate that nicotinamide administration normalizes hepatic antioxidant enzymes reducing oxidative stress Clinical trials have shown dose-dependent upregulation of frataxin expression following sustained nicotinamide treatment suggesting therapeutic potential in disorders like Friedreich s ataxia
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