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Apexbio Technology LLC Nigericin sodium salt 28643-80-3 50 mg
SDP

Catalog No. 5000063532
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Nigericin sodium salt is a lipid-soluble ionophore functioning by facilitating K /H exchange across biological membranes Experimentally it modulates intracellular pH levels through its ion-transport activity influencing cellular processes sensitive to pH homeostasis such as platelet aggregation and energy metabolism pathways Nigericin exhibits limited inhibitory effects on platelet aggregation induced by agonists like thrombin or ADP correlating primarily with reductions in cytoplasmic pH Additionally nigericin has demonstrated capacity to transport Pb2 ions across membranes selectively suggesting potential utility in experimental models targeting metal ion homeostasis and heavy-metal toxicity research Nigericin exhibits inhibitory activity on ATP-driven transhydrogenase reactions showing varied IC50 depending upon ATP concentrations and experimental conditions (IC50 values typically range from low micromolar to submillimolar concentrations)

Catalog No. 50-000-63532 Supplier Apexbio Technology LLC Supplier No. B764450
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Nigericin sodium salt is a lipid-soluble ionophore functioning by facilitating K /H exchange across biological membranes Experimentally it modulates intracellular pH levels through its ion-transport activity influencing cellular processes sensitive to pH homeostasis such as platelet aggregation and energy metabolism pathways Nigericin exhibits limited inhibitory effects on platelet aggregation induced by agonists like thrombin or ADP correlating primarily with reductions in cytoplasmic pH Additionally nigericin has demonstrated capacity to transport Pb2 ions across membranes selectively suggesting potential utility in experimental models targeting metal ion homeostasis and heavy-metal toxicity research Nigericin exhibits inhibitory activity on ATP-driven transhydrogenase reactions showing varied IC50 depending upon ATP concentrations and experimental conditions (IC50 values typically range from low micromolar to submillimolar concentrations)

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