Nigericin sodium salt, 98+%

Description

A potassium ionophore | CAS: 28643-80-3 | C40H68O11 | 724.973 g/mol

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

Solubility
Soluble in chloroform, methanol or ethanol

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents, acids, bases and heat.

Specifications

• CAS: 28643-80-3
• Color: White
• Molecular Formula: C40H68O11
• Quantity: 10 mg
• MDL Number: MFCD00036825
• UN Number: UN3462
• Beilstein: 3892398
• Merck Index: 14,6541
• Synonym: nigericin
• Solubility Information: Soluble in chloroform, methanol or ethanol
• InChI Key: DANUORFCFTYTSZ-FBMOGUJMSA-N
• SMILES: CC1CCC(OC1C(C)C(=O)O)CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC
• IUPAC Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-
• Molecular Weight (g/mol): 724.973
• PubChem CID: 123134611
• Formula Weight: 746.94
• Percent Purity: ≥98%
• Physical Form: Powder
• Chemical Name or Material: Nigericin sodium salt

Safety and Handling

Hazard Category	H301-H315-H319-H335
Hazard Statement	GHS H Statement H301-H315-H319-H335 Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
RTECSNumber	QT6840000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only