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STEMCELL Technologies Nilotinib, Size: 10 mg
Supplier: STEMCELL Technologies 73302
Inhibit BCR/ABL and ABL with Nilotinib (Kitagawa et al. Genes Cells, 2013). This tyrosine kinase inhibitor binds to the ATP-binding pocket of ABL with higher affinity than imatinib (Manley et al. ASH Annu Meet Abstr, 2006). Nilotinib has various applications in cancer research, such as inhibiting cellular proliferation in many wild-type and mutant forms of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML) cells (Verstovsek et al. Cancer, 2005; O’Hare, Cancer Res, 2005). Nilotinib is also used to inhibit cell proliferation and progression through S phase in human lung cell line A549 through transcriptional changes in DNA helicase complex, cyclins, and cyclin-dependent kinases (Ji et al. PLoS Comput Biol, 2009). Minocycline is supplied as a crystalline solid with ≥95% purity; Molecular weight 493.9 g/mol; CAS Number 641571-10-0. Visit STEMCELL.com for more information and related products.
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