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AdipoGen Nimbolide
Supplier: AdipoGen CDXN0360M005
Chemical. CAS 25990-37-8. Formula C27H30O7. MW 466.52. Nimbolide is a limonoid tetranortriterpenoid shown to exhibit anti-malarial, anti-bacterial, anti-inflammatory, anti-obesity and anti-cancer activities. Nimbolide induces cell cycle arrest, DNA damage and apoptosis, and modulates autophagy in cancer cell lines. It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the pro-apoptotic proteins Bax, caspase-3 and PARP. Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. This compound impairs proliferation of triple-negative breast cancer cell lines. Nimbolide also induces apoptotic cell death in a Waldenstroms macroglobulinemia cell line BCWM1 and inhibits tumor growth in a xenograft model of Waldenstroms macroglobulinemia.
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