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Medchemexpress LLC Nimustine hydrochloride (ACNU) | 55661-38-6 | 98.2% | 309.15 | 1 ML
Supplier: Medchemexpress LLC HY13703A10MM/1ML
Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine. It functions as an alkylating agent by inducing DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), which activates the DNA damage response (DDR) signaling pathway. It also activates the p38 MAPK/JNK signaling pathway and demonstrates antitumor activity.
- Induces DNA double-strand breaks and inter-strand crosslinks.
- Activates DNA damage response signaling.
- Activates p38 MAPK/JNK signaling.
- Demonstrates antitumor activity.
- Exhibits cytotoxicity against human U87MG cells.
- Induces apoptosis in LN-229 cells.
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