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AdipoGen Nintedanib free base
SDP

Supplier:  AdipoGen CDXN0321M100

Encompass_Preferred

Chemical. CAS 656247-17-5. Formula C31H33N5O4. MW 539.6. Nintedanib is an orally bioavailable and potent triple angiokinase inhibitor with potential antiangiogenic and antineoplastic activities. It targets the proangiogenic pathways mediated by the the receptor tyrosine kinases VEGFR1/2/3 IC50=13-34nM, FGFR1/2/3 IC50=37-108nM and PDGFRalpha/beta IC50=59-65nM, which may result in the induction of endothelial cell apoptosis, a reduction in tumor vasculature, and the inhibition of tumor cell proliferation and migration. Nintedanib competitively binds to the ATP binding-pocket of these receptors, resulting in interference with receptor dimerization and blocking intracellular signaling critical for the proliferation and survival of angiogenesis-related endothelial cells, pericytes and vascular smooth muscle cells.

Catalog No. 50-256-0368


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