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Selleck Chemical LLC Niraparib (MK-4827) 5mg 1038915-60-4
Supplier: Selleck Chemical LLC S27415MG
Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP¿DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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