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Medchemexpress LLC NITD-688 (EYU-688) | 2407227-31-8 | > 98.0% | 500.68 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13854350MG

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NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein, used in the research of dengue virus (DENV). It demonstrates antiviral activity against all four serotypes of dengue virus (DENV) and shows excellent antiviral efficacy in infected AG129 mice.

  • Orally active pan-serotype inhibitor of the dengue virus NS4B protein
  • Used in research of dengue virus (DENV)
  • Antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM
  • Antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM
  • Directly binds to wild-type but not mutant NS4B protein
  • Demonstrates a 1.16-log reduction in viremia in infected AG129 mice
  • Well tolerated in rats and dogs in toxicology studies

Catalog No. 50-003-50467


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