Nitrendipine

Description

L-type calcium channel blocker | CAS: 39562-70-4 | C18H20N2O6 | 360.366 g/mol

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 39562-70-4
• Molecular Formula: C18H20N2O6
• Molecular Weight (g/mol): 360.366
• MDL Number: MFCD00082255
• InChI Key: PVHUJELLJLJGLN-UHFFFAOYSA-N
• Synonym: nitrendipine, bayotensin, baypress, nidrel, nitrendipinum, nitrendipino, bylotensin, nitrendipin, deiten, nitrepin
• PubChem CID: 4507
• ChEBI: CHEBI:7582
• IUPAC Name: 5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C

• Color: Yellow to Green
• Quantity: 500 mg
• Merck Index: 14,6576
• Solubility Information: Soluble in DMSO (17.5mg/ml),methanol (15mg/ml),ethyl acetate,and ethanol (25 mM). Insoluble in water.
• Formula Weight: 360.36
• Physical Form: Powder
• Chemical Name or Material: Nitrendipine

Safety and Handling

Hazard Category	H302+H312+H332
Hazard Statement	GHS H Statement H302-H312-H332 Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P312-P330-P363-P501c
EINECSNumber	254-513-1
RTECSNumber	US5653000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only