AdipoGen anti-NLRC3 (mouse), mAb (Eowyn-1) (100 µg)

Supplier:  AdipoGen AG20B0067C100

Monoclonal Antibody. Detects overexpressed mouse NLRC3. Doest not detect human NLRC3. Although NLRC3 (mouse), mAb (Eowyn-1) is strong and specific (see figure), the endogenous protein has not been detected yet with this antibody (using NLRC3 KO versus WT immune cells). NLRC3 protein is probably expressed at very low levels or its translation/stability is triggered by stimuli still to be discovered. Isotype: Mouse IgG1. Clone: Eowyn-1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 negatively regulates pro-IL-1beta maturation and inhibits TLR-dependent activation of the transcription factor NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses.

Catalog No. 50-205-2980