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AdipoGen NLRP1b ms mAb 2A12
Supplier: AdipoGen AG20B0084C100
Monoclonal Antibody. Recognizes mouse and rat NLRP1b. Detects mouse NLRP1b and also both the B6 and 129 alleles of murine NLRP1b. Does not cross-react with human NLRP1. Applications WB. Clone 2A12. Isotype Mouse IgG2b. AK10383 The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. As inflammasome-forming sensor protein, NLRP1b, upon detection of microbial molecules or pathogen-encoded activities, serves as a platform for the recruitment and activation of proinflammatory caspases including caspase-1 through a caspase activation and recruitment domain CARD. Active caspase-1 mediates the maturation and release of the proinflammatory cytokines interleukin IL-1beta and IL-18.
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