Medchemexpress LLC Nls-Stax-h (Tfa) | 2872559-21-0 | 98.9% | 3559.28 | 100 UG

Supplier:  Medchemexpress LLC HYP2272A500UG

Nls-Stax-h is a selective, cell-permeable, stapled peptide that acts as a Wnt signaling inhibitor. It has an Ic50 of 1.4 μM and effectively inhibits β-catenin-transcription factor interactions. This compound demonstrates anti-proliferative effects on cancer cells.

• Selective Wnt signaling inhibitor.
• Cell-permeable.
• Stapled peptide.
• Inhibits β-catenin-transcription factor interactions.
• Shows anti-proliferation of cancer cells.
• Inhibits proliferation of colorectal cancer cells at 10 μM over 72 h, reducing viability by more than 80% in SW-480 and DLD-1 cells.
• Inhibits migration of colorectal cancer cells at 5 and 10 μM over 24 h, resulting in dose-dependent inhibition of wound closure (52% at 5 μM, and 24% at 10 μM in DLD-1 cells).

Catalog No. 50-004-23399