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AdipoGen NMNAT2 hrecHis MultiPack
Supplier: AdipoGen AG40A0153T3010
Protein. Human NMNA2 aa 2-307 is fused at the N-terminus to a His-tag. Source E. coli. Lyophilized in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl plus 0.025% CHAPS. Purity >90% SDS-PAGE. Nicotinamide mononucleotide adenylyltransferase 2 NMNAT2 catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. Can also use the deamidated form nicotinic acid mononucleotide NaMN as a substrate but with lower efficiency. NMNAT2 also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD. It is highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. NMNAT2 is also found in the heart, skeletal muscle, pancreas and islets of Langerhans. NMNAT2 is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration axon degeneration induced by nerve injury, whereas NMNAT overexpression rescues axons from degeneration.
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