AdipoGen NMNAT3 hHishighly active

Supplier:  AdipoGen AG40T0093C050

Protein. Human full-length NMNAT3 aa 1-252 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 50mM TRIS-HCl, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol. Purity >95% SDS-PAGE. Mitochondrial NMNAT isoform. Catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. Can also use the deamidated form of nicotinic acid mononucleotide NAMN as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD, NADH, NAAD, nicotinic acid adenine dinucleotide phosphate NHD, nicotinamide guanine dinucleotide NGD as substrates. Fails to cleave phosphorylated dinucleotides NADP, NADPH and NAADP. Protects against axonal degeneration following injury.

Catalog No. 50-256-2768