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Cayman Chemical NMS-1286937 10mg
Supplier: Cayman Chemical 2876210 MG
An inhibitor of Plk1 (IC50 = 2 nM); selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both); inhibits proliferation of A2780 cells (IC50 = 42 nM); halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day; induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11
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