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Apexbio Technology LLC NMS-873 1418013-75-8 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B21685.1

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NMS-873 (CAS 1418013-75-8) is a selective inhibitor of the ATPase VCP/p97 demonstrating inhibitory activity with an IC50 value of 30 nM It targets wild-type VCP as well as VCPC522T mutants without disrupting VCP oligomerization NMS-873 exhibits selectivity against other AAA ATPases HSP90 and various kinases In tumor cell lines including HCT-116 treatment with NMS-873 induces accumulation of polyubiquitinated proteins and stabilization of cyclin E and Mcl-1 leading to altered cell-cycle distribution and reduced cell proliferation NMS-873 shows cytotoxicity across blood cancer and solid tumor cell models (IC50 values 0 08 2 M) supporting its utility in oncology research

Catalog No. 50-000-63702


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