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AdipoGen Nod1 human pAb AL184
Supplier: AdipoGen AG25B0013C050
Polyclonal Antibody. Recognizes human Nod1. Source Rabbit. Applications WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Nod CARD4 is a cytosolic pattern recognition molecule PRRs of the NLR NOD-like receptor family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid meso-DAP-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.
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