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Medchemexpress LLC Nolatrexed dihydrochloride | 152946-68-4 | 98.5% | 357.26 | 1 ML
Supplier: Medchemexpress LLC HY10847410MM/1ML
Nolatrexed dihydrochloride is an orally active, non-competitive lipophilic inhibitor of thymidylate synthase. It interacts at the folate cofactor binding site of the enzyme, increases sulfotransferases, and induces cell cycle arrest in the S phase of cancer cells. It also exhibits anticancer activity against cervical cancer.
- Orally active
- Non-competitive lipophilic inhibitor of thymidylate synthase (Ki of 11 nM for human thymidylate synthase)
- Interacts at the folate cofactor binding site of the enzyme
- Increases sulfotransferases
- Induces cell cycle arrest in S phase of cancer cells
- Exhibits anticancer activity against cervical cancer
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