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Medchemexpress LLC Nolatrexed dihydrochloride | 152946-68-4 | 98.5% | 357.26 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108474
Nolatrexed dihydrochloride (AG 337) is an orally active, non-competitive, lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. It interacts at the folate cofactor binding site of the enzyme, increases sulfotransferases, and induces cell cycle arrest in the S phase of cancer cells. It also exhibits anticancer activity against cervical cancer.
- Orally active and non-competitive lipophilic inhibitor of thymidylate synthase.
- Interacts at the folate cofactor binding site of the enzyme.
- Increases sulfotransferases.
- Induces cell cycle arrest in S phase of cancer cells.
- Exhibits anticancer activity against cervical cancer.
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