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Cayman Chemical NolatrexedhydrochlorIde 10mg

Supplier: Cayman Chemical 2924710 MG
A thymidylate synthase inhibitor (Ki = 11 nM); inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM); inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine; induces cell cycle arrest at the S phase in L1210 cells at 0.7 and 3.5 μM; increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model at 25-200 mg/kg
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