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Medchemexpress LLC Nomifensine maleate | 32795-47-4 | 98.7% | 100 MG
SDP

Supplier:  Medchemexpress LLC HYB1110A100MG

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Nomifensine maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. It inhibits the uptake of NE, DA, and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM, and 830 nM, and Ki values of 4.7 nM, 26 nM, and 4000 nM, respectively. It demonstrates antidepressant and analgesic effects and is utilized in research pertaining to neurodegenerative diseases, compound addiction, and pain.

  • Reduces response latency and increases activity in WKY rats.
  • Significantly inhibits dopamine neuronal firing in the ventral tegmental area of SD rats.
  • Produces analgesia in the formaldehyde test.
  • Suppresses neurotoxicity induced by MPTP.

Catalog No. 50-004-12562


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