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Cayman Chemical Nonafluoro-3 6-dioxaheptanoic

Supplier: Cayman Chemical 3791750 MG

A histamine H3 receptor antagonist (Kis 0.13 0.68 and 1.74 nM for the recombinant human rat and mouse receptors respectively) selective for the histamine H3 receptor over a panel of 50 receptors and ion channels at 1 UM prevents imetit-induced decreases in forskolin-stimulated cAMP accumulation in HEK293-Gao cells expressing the human histamine H3 receptor (pA2 9.06) inhibits intake R-(–)-a-methylhistamine-induced increases in water intake and reverses scopolamine-induced memory deficits in the passive avoidance test in rats increases hindlimb grip force in a rat model of monoiodoacetate-induced osteoarthritic pain and increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain (ED50s 0.77 and 1.5 mg/kg i.p. respectively)
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