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Apexbio Technology LLC Nonivamide (Capsaicin Analog) 2444-46-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A32785.1
Nonivamide (CAS 2444-46-4) a structural analog of capsaicin found in chili peppers is an agonist of the transient receptor potential vanilloid subtype 1 (TRPV1) a thermally activated calcium ion channel Binding of nonivamide to TRPV1 lowers the channel activation threshold below physiological temperature altering cellular calcium influx Related compounds have demonstrated notable antiproliferative effects triggering apoptosis through pathways involving downregulation of anti-apoptotic Bcl-2 proteins activation of caspases mitochondrial dysfunction and differentiation induction in diverse cancer cell lines including glioma and breast cancer cells As a result of these properties nonivamide serves as a valuable tool for investigating TRPV1-mediated signaling and anticancer mechanisms in biomedical research
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