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Apexbio Technology LLC Nordihydroguaiaretic acid 500-38-9 500mg
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Catalog No. 5000093418
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Nordihydroguaiaretic acid (NDGA CAS 500-38-9) is a naturally occurring phenolic compound derived from Larrea divaricata NDGA has been shown to inhibit the mTORC1 complex by disrupting the mTOR-Raptor interaction suppressing both amino acid- and insulin-induced mTORC1 activation In hepatocyte models NDGA increases PPAR promoter activity and counteracts fatty acid-mediated suppression of PPAR expression an effect abolished by PPAR silencing In vivo NDGA induces Nrf2 nuclear translocation and confers protection against renal injury in animal models NDGA and its analogs are under clinical investigation for refractory solid tumors with additional research exploring its effects in nonmetastatic relapsed prostate cancer

Catalog No. 50-000-93418 Supplier Apexbio Technology LLC Supplier No. A3664500
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Nordihydroguaiaretic acid (NDGA CAS 500-38-9) is a naturally occurring phenolic compound derived from Larrea divaricata NDGA has been shown to inhibit the mTORC1 complex by disrupting the mTOR-Raptor interaction suppressing both amino acid- and insulin-induced mTORC1 activation In hepatocyte models NDGA increases PPAR promoter activity and counteracts fatty acid-mediated suppression of PPAR expression an effect abolished by PPAR silencing In vivo NDGA induces Nrf2 nuclear translocation and confers protection against renal injury in animal models NDGA and its analogs are under clinical investigation for refractory solid tumors with additional research exploring its effects in nonmetastatic relapsed prostate cancer

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