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Medchemexpress LLC Norfluoxetine hydrochloride | 57226-68-3 | MFCD00078972 | 99.6% | 331.76 | 50 MG
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Supplier:  Medchemexpress LLC HYW01123550MG

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Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). It also has anticonvulsant activity.

  • Inhibits 5-HT uptake.
  • Inhibits CaV3.3 T current (IC50 = 5 μM).
  • Exhibits anticonvulsant activity.
  • Pretreatment with Norfluoxetine hydrochloride (20 mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy.

Catalog No. 50-003-66561


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