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Apexbio Technology LLC Norharmane 244-63-3 1g
Supplier: Apexbio Technology LLC C49821000
Norharmane (CAS 244-63-3) is a naturally occurring -carboline alkaloid originally isolated from plants of the Zygophyllaceae family and also present in cooked meats tobacco smoke and coffee Functioning as a co-mutagen norharmane does not display mutagenicity in Salmonella typhimurium TA98 and TA100 assays with or without metabolic activation (S9 mix) but exhibits mutagenic activity in combination with certain non-mutagenic aromatic amines facilitating DNA adduct formation At micromolar concentrations norharmane has been shown to inhibit monoamine oxidase types A and B Norharmane s roles in modulating mutagenesis and enzyme inhibition support its utility in studies of chemical carcinogenesis and neurobiology
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