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Medchemexpress LLC Norisoboldine | 23599-69-1 | 313.35 | 50 MG
Supplier: Medchemexpress LLC HYN058650MG
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. It is a major isoquinoline alkaloid found in Radix Linderae and can be used for the research of rheumatoid arthritis and ulcerative colitis.
- Activates AhR under hypoxic microenvironment.
- Downregulates mRNA expression of miR-31.
- Inhibits glycolysis in hypoxia.
- Promotes Treg differentiation in hypoxia.
- Facilitates disassociation of HSP90/AhR complexes.
- Induces nuclear translocation of AhR.
- Forms AhR/ARNT complexes.
- Reduces severity of joint swelling and erythema in animal models.
- Enhances CYP1A1 expression in colons.
- Suppresses expressions of Glut1 and HK2 in colons.
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