Cayman Chemical NorquetIapIn 10mg

Supplier:  Cayman Chemical 3668710 MG

An active metabolite of quetiapine; selectively inhibits NET (IC50 = 12 nM) over SERT and DAT (IC50s = 988 and >10,000 nM, respectively); binds to the histamine H1 receptor (Ki = 3.5 nM), as well as 5-HT1, 5-HT2, and 5-HT7, α1- and α2-adrenergic, dopamine D1-D5, and M1-M5 muscarinic receptors (Kis = 45-1,117 nM, 95-736, 196-1,419, and 23-453 nM, respectively); an antagonist at histamine H1, α1A- and α1D-adrenergic, M1, M3, and M5 muscarinic receptors in a concentration-dependent manner and an agonist at the 5-HT1A receptor (EC50 = 4,898 nM); reduces increases in immobility time in Vmat2 heterozygous mice at 0.1, 0.5, and 1 mg/kg

Catalog No. 50-291-3532